Baseline 15 m 30 m Max p sPAP 66.4 ± 13.5 59.9 ± 15.4 53.3 ± 12.3 48.4 ± 13.7 0.002 dPAP 29.7 ± 7.7 25.8 ± 7.5 23.4 ± 6.6 20.3 ± 6.5 0.005 mPAP 43.8 ± 8.8 39.5 ± 9.7 35 ± 8.5 31.3 ± 8.7 <0.001 TPG 20.3 ± 4.4 16.4 ± 5.8 13.8 ± 4.6 11.5 ± 3.5 <0.001 PRV 6.1 ± 2.6 4.4 ± 2.4 3.7 ± 1.8 3 ± 1.4 0.001 PWP 23 ± 7.7 21.5 ± 7.7 20.8 ± 7.7 20.1 ± 7.3 0.56 CO 3.7 ± 1.4 4.4 ± 1.2 4.2 ± 1.2 4.5 ± 1.4 0.005 MBP 68,5 ± 34     57.8 ± 34 0.003 SvO2 57 ± 10.9 58 ± 10.2 61.1 ± 7.7 63 ± 8.4 0.08

Table 2: Evolution of the different hemodynamic parameters measured during the acute vasodilator test with sildenafil in the “PH” group; baseline and at 15, 30 and 45 minutes (considered the maximum effect); sPAP: systolic pulmonary artery pressure mmHg; dPAP: diastolic pulmonary artery pressure mmHg; mPAP: mean pulmonary artery pressure mmHg; TPG: transpulmonary gradient; PVR: pulmonary vascular resistances WU, PWP: pulmonary wedge pressure mmHg; CO: cardiac output l/min; MBP: Mean blood pressure mmHg; SvO2: mixed venous oxygen saturation.