Figure 2: (A) Concentration-response curves for LASSBio-1366 in pulmonary artery rings from normal Wistar rats, contracted with phenylephrine (10-5 mol/L), in the presence or absence of ZM 241385 (10-7 mol/L). Data are mean ± SEM (n=6). *P<0.05 compared to control. (B) Interactions of the co-crystallized antagonist ZM241385 in the adenosine A2A receptor (PDB ID: 3EML); (C) Binding mode predicted of LASSBio-1366 and its interactions in adenosine A2A receptor.