Mutation type/alteration

Adenocarcinoma subtype

EGFR

Well differentiated, lepidic/in situ non mucinous, papillary and/or micropapillary

K-RAS

Mucinous (invasive or lepidic/in situ)

B-RAF

Papillary

ELM4-ALK

Solid or with isolated signet-ring cell component

CTNNB1 (Beta-catenin)

Clear cell or foetal

Table 1: Possible associations between genetic alterations and histological subtype of lung adenocarcinoma