Cluster Proteins Enriched Terms GO Ids GO term Level p-value Bonferonni-correction                 1 135 18 GO:0043066 negative regulation of apoptotic process 7 6.99253×10−09 3.41235×10−06       GO:0006987 activation of signaling protein activityinvolved in unfolded protein response 11 1.80733×10−08 8.81979×10−06 2 121 19 GO:0010467 gene expression 4 0.00000 0.00000       GO:0006120 mitochondrial electron transport, NADHto ubiquinone 9 1.37596×10−10 4.93969×10−08 3 95 29 GO:0044281 small molecule metabolic process 3 0.00000 0.00000       GO:0006006 glucose metabolic process 7 2.69909×10−10 1.08233×10−07 4 152 56 GO:0042738 exogenous drug catabolic process 10 0.00000 0.00000       GO:0071236 cellular response to antibiotic 6 3.68974×10−05 0.02007 5 77 25 GO:0044255 cellular lipid metabolic process 4 0.00000 0.00000       GO:0033540 fatty acid beta-oxidation usingacyl-CoA oxidase 11 0.00000 0.00000 6 105 38 GO:0034641 cellular nitrogen compound metabolicprocess 3 0.00000 0.00000       GO:0002376 immune system process 1 1.25410×10−05 0.00515 7 50 16 GO:0006183 GTP biosynthetic process 11 0.00000 0.00000       GO:0006283 transcription-coupled nucleotide-excision repair 9 2.02819×10−08 4.94879×10−06 8 112 26 GO:0034220 ion transmembrane transport 6 1.95507×10−10 1.302076×10−07       GO:0008543 fibroblast growth factor receptorsignaling pathway 8 1.89730×10−09 1.26360×10−06 9 39 9 GO:0006457 protein folding 6 0.00000 0.00000       GO:0000398 mRNA splicing, via spliceosome 11 3.49331×10−11 4.89063×10−09 10 1 2 GO:0006950 response to stress 2 0.00590 0.01179       GO:0006457 protein folding 6 0.01383 0.02765 11 2 12 GO:0050796 regulation of insulin secretion 8 7.81617×10−06 0.00016       GO:0006112 energy reserve metabolic process 5 1.25409×10−05 0.00025

Table 1: Clustering human proteins predicted to interact with MTB proteins. Different clusters identified and the two most statistically relevant GO biological process terms associated with a given gene list in each cluster.