Drug Gene Function
Isoniazid katG Catalase peroxidase
inhA Enoyl-acyl carrier protein reductase
ahpC Alkyl-hydroperoxide reductase
kasA Ketoacyl acyl carrier protein synthetase
Rifampicin rpoB β-subunit of the RNA polymerase
Pyrazinamide pncA Pyrazinamidase
Streptomycin rpsL Ribosomal S12 protein
rrs 16S rRNA
Amikacin/kanamycin rrs 16S rRNA
Capreomycin rrs 16S rRNA
tlyA rRNA methyltransferase
Fluorochinolone gyrA, gyrB DNA gyrase
Ethambutol embCAB Arabinosyl transferase
Ethionamide gyrB DNA gyrase
inhA Enoyl-acyl carrier protein reductase
Table 2: Genetic basis of drug resistance in Mycobacterium tuberculosis [51-53].