No. of mice to be sacrificed at the following time points
Day  -13 Day 0 Wk 1 Wk 2 Wk 4 Wk 8 Wk 16 Total
Control Regimens
Untreated 10 10 5 5 5 5 5 45
RIF     5 5 5 5 5 25
INH     5 5 5 5 5 25
PZA     5 5 5 5 5 25
RIF+INH     5 5 5 5 5 25
Test Regimens
RIF+PZA     5 5 5 5 5 25
INH+PZA     5 5 5 5 5 25
RIF+INH+PZA     5 5 5 5 5 25
Total Mice 10 10 40 40 40 40 40 220
Treatment was initiated two weeks after infection at Day 0 and was administered for 16 weeks.
Table 1: Scheme for experiment 1: assessment of PZA activity in M. bovis-infected mice.