Mean (SD) log10 M. bovis CFU counts in mouse lungs at the following time points
Day  -13 Day 0 Wk 1 Wk 2 Wk 4 Wk 8 Wk 16
Control Regimens
Untreated 3.73 (0.13) 6.56 (0.12) 7.67 (0.17) 8.69 (0.71) 8.11 (0.33) 8.79 (0.49)*  
RIF     7.15 (0.30) 6.87 (0.29) 6.75 (0.08) 6.09 (0.16) 5.79 (0.26)
INH     6.46 (0.11) 6.31 (0.22) 5.70 (0.16) 4.69 (0.31) 3.86 (0.20)
PZA     7.75 (0.21) 8.17 (0.17) 8.31 (0.62) 7.5**  
RIF+INH     5.71 (0.19) 5.03 (0.05) 4.40 (0.18) 2.72 (0.14) 0
Test Regimens
RIF+PZA     7.04 (0.19) 7.27 (0.51) 6.96 (0.08) 5.94 (0.23) 5.82 (0.19)
INH+PZA     6.99 (0.52) 6.38 (0.36) 5.80 (0.23) 5.19 (0.36) 4.12 (0.74)
RIF+INH+PZA     5.47 (0.24) 5.09 (0.28) 4.39 (0.14) 2.63 (0.23) 0.68 (1.20)
Treatment was initiated two weeks after infection at Day 0 and was administered for 16 weeks. Drugs were administered 5 days per week at the following doses:
RIF, 10 mg/kg; INH, 10 mg/kg; PZA, 150 mg/kg.
*CFU counts from two surviving mice.
**CFU counts from a single mouse that survived to this time point.
Table 2: Lung CFU counts in M. bovis-infected mice treated with different drug regimens with and without PZA (Experiment 1).