Figure 2: Genetic organization of the mycolactone biosynthetic cluster from pMUM001, pMUM002 and proposed organization for pMUM003. Mycolactone PKS module and domain structure is outlined, with the figure key showing the type of domains present in each of the modules. The mycolactone modules are colour coded based on the type of module responsible for the addition of each two-carbon unit. Shaded modules indicate that the DNA sequence of these regions is unknown or not yet confirmed. *Organisation of mlsA1 and mlsA2 for all pMUM examined to date, based upon toxin structures. From Pidot et al. [41].