Question TB Experts (n=29) Rheumatology Experts (n=12)   % Agreementb Median Range % Agreementb Median Range PValuec I would stop therapy with TNFAB 61 4 1-5 92 4 1-5 0.18 I would start empiric therapy for TB 64 4 1-5 58 4 1-5 0.81 How long would you wait to start TNFAB therapy? -- 4 1-7 -- 5 1-7 0.17

TNFAB: TNF-α blocking; TST: Tuberculin Skin Test

aLikert Response: 1, restart TNFAB immediate; 2, 2 weeks; 3, 1 month; 4, 2 months; 5, 3 months; 6, 4 months; 7,wait for completion of TB therapy (excluding from the analysis: 8, never restart TNFAB; 9, other§) bPercent of individuals within each group who select ”agree“ or ”strongly agree“ cComparison of distribution between groups by Wilcoxon one-way analysis of variance

Table 2: Expert Opinion Regarding TNFAB and Empiric TB Therapy for Individuals with Suspected TB While on TNFAB Therapya.