Adverse event Grade 1 Grade 2 Grade 3 Grade 4 Grade 5 Mucositis oral (clinical exam) Erythema of the mucosa Patchy ulcerations or pseudo membranes Confluent ulceations or pseudo membranes; bleeding with minor trauma Tissue necrosis; significant spontaneous bleeding Death Mucositis oral (functional/ symptomatic) Asymptomatic or mild symptoms; intervention not indicated Moderate pain; not interfering with oral intake; modified diet indicated Severe pain; interfering with oral intake Life-threatening consequences; urgent intervention indicated Death

Table 2: Common Terminology Criteria for Adverse Events (CTCAE) v4.0.