| |
R-warfarin |
S-warfarin |
Pharmacokinetic
parameters |
Placebo +warfarin |
LCZ696+warfarin |
GMR* (90% CI) |
Placebo +warfarin |
LCZ696+warfarin |
GMR*(90% CI) |
| |
N=25 |
N=25 |
|
N=25 |
N=25 |
|
Tmax
(hours; median [range]) |
2.0 (0.5–4.0) |
2.0 (0.5–4.0) |
– |
1.0 (0.5–4.0) |
1.0 (0.5–4.0) |
– |
| Cmax (ng·mL−1) |
1399 ± 234 |
1343 ± 249 |
0.96 (0.91, 1.03) |
1444 ± 271 |
1367 ± 277 |
0.95 (0.88, 1.03) |
AUClast
(ng·h·mL−1) |
61570 ± 11991 |
59860 ± 12357 |
0.99 (0.97, 1.01) |
49810 ± 18059 |
49180 ± 19549 |
0.98 (0.95, 1.01) |
AUCinf
(ng·h·mL−1) |
69010 ± 15853 |
66400 ± 16315 |
0.98 (0.96, 1.00) |
56360 ± 28321 |
55300 ± 30143 |
0.97 (0.95, 1.00) |
t1/2
(hours) |
43.9 ± 8.0 |
41.8 ± 7.4 |
– |
40.3 ± 14.8 |
38.5 ± 14.1 |
– |
Data are shown as mean (±SD) except for Tmax values, which are presented as median (min–max).*Ratio = (LCZ696+warfarin)/LCZ696.
AUC, area under the plasma concentration-time curve; AUClast, AUC up to the last measurable concentration; AUCinf, AUC with the last concentration extrapolated; Cmax maximum (peak) concentration; CI, confidence interval; GMR, geometric mean ratio; Tmax, time to reach maximum (peak) concentration following drug administration; t1/2, half-life; SD, standard deviation. |
|
