Figure 1: Flow chart of components parts of the Immune system Boosting Machine. ICE means inter cutaneuos exchange of heat, physiol mean physiology, TG implies thermal gradients. DH: heat enthalpy, atm: atmosphere, physiol: physiology, biochem: biochemistry, R: relative humidity, CNS: central nervous system, peri: peripheral, exh: exchange, DH: change in heat content of the system. Note that areas where adjustment of values favours the following (The TGs), (1) Heat flow from high to high region (enable manipulation of cellular and physiological events example mild fatal temperature of 42℃ maintained per unit time, for at this values maximum benefits of immune boost and hyperthermia are obtained (2) Heat flow from low to high region(to ensure that balanced steady state is reached, after exposure to extremes of 40℃ or 43℃ i.e. about increment of 3 degree Celsius) note exposure per unit time to the machine at increment of 3 will make survival values increase by 10% see estimated result from past findings below. (3) Heat flow from high to low region(ensure endurance, relaxation, invigoration to tolerable state of discomfort which occur during treatments) effectively will prevent denaturing effect of high temperature, restore functional integrity of the cells, maintain electrolyte balance, fluid composition, volume and all the steady state parameters, and time interval for data collection (as read and interpreted by data interpreter attached to physiologic, biochemical and lab test kits respectively), IP values may necessitate increase or decrease in heat source, increase in room temperature, increase in negative or positive values of the TGbIII exchangers as the case may require, so that the hypothalamic thermostat is steadied, increase or lower at TGd, TGe, TGf in directions that favours prolonged immune boost and hyperthamal effects , on the other hand once maximum value of immune boost or hyperthermal therapy is reached base on ideal time frame deem safe for the individual patients or healthy ones, then adjustment will be done to shift primarily the mildly fatal values of 34 to 41 reading on the thermometer, in addition the physio biochemical values adjustment and shift will likewise follow same pattern, exposure to the machine could be done in both healthy and non healthy individuals, given that both state of health need strong functional immunity for survival, all regulations and adjustments will be base on accurately determined experimental values, for instance presumably, 5 hours exposure per month may be done to achieved the objective of long time immune boost and thus prolong life span, I posit that in sickness antipyretic use need be withhold until patients are expose to the machine for three days each, in a regulated manner, for preceding 3 days of exposure maximum benefit of the immune boost would have been realised. Variations no doubt could impaire body functions, thus sensors and all other body parametric values determiners will check mate any dangerous variations that may arise during exposure accurately, so that by proxy the hypothalamus will be regulated by the machine in all ramification to maintained tolerable side effects (mainly discomforts). Frequent treatment of fever and use of antipyretic without adequate exposure to the ensuing fever events(immune boost), research showed, could lower life expectance or life span in that the physiologically naturally formidable body ability to strength it immune systems is frequently compromised and as a result humans nowadays have very low resistance to most diseases incidence, treatments most time involve use of substance which do not give cure owing to weakened state of the immune system, some of the substance may affect functional state of the most organs adversely, some drug used at lower dose in a body with strong immune state tend to be efficacious, thus proper frequent exposure of healthy or ill individuals to the immune boosting machine will boost the immune system and also ensure use of low dose drug in treatment of certain diseases (Cancer, HIV/AIDS, Diabetes, etc), finally compared to adverse effects of other treatment methods, adoption and use of the immune boosting machine may cure certain disease without the need for further treatment as mentioned, it could boost the immune system in healthy individuals, reduced incidence of aging(owing to PARPS actions), boost immune power, shift life span and life expectancy values to their extremes (80 to 125 years) and then increase survival values at least by 10% per exposure to the machine.