Figure 3: Atherosclerosis measurements in SPX-106T and control mice A) sinus of valsalva, B) aortic arch, and C) thoracic aorta. All atherosclerosis measurements showed significant differences between SPX-106T and control groups. Sinus of valsalva and aortic arch had p<0.01 while thoracic aorta had a p<0.05. Enface measurements of aortic arch and thoracic aorta were done by 2 separate blinded individual and seconded by the investigator in the same manner.