Dosage Form Drug Product and Polymer Used
Gels Retin-A Micro® (carbomer 974P (0.04%), carbomer 934P (0.1%) Benzamycin® Pak (hydroxypropyl cellulose, carbomer 934) Differin® (carbomer 940, poloxamer 124)
Creams Tazorac® (carbomer 934P, carbomer 1342) Estrace® (hypromellose 2208 (4000 cps)) Bactroban (cetomacrogol 1000, mineral oil, xanthan gum)
Lotions Elocon® (hydroxypropylcellulose) Cutivate® (propylene glycol, cetomacrogol 1000)
Pastes Aphthasol® (gelatin, pectin, sodium carboxymethylcellulose) Kenalog® in Orabase /Oralone® (gelatin, pectin, and sodiumcarboxymethylcellulose)
Nasal Sprays Flonase® (microcrystalline cellulose and carboxymethylcellulose sodium) Astepro® (hypromellose) Lazanda® (pectin)
Suspensions Omnicef® (xanthan gum, guar gum) Augmentin® (xanthan gum, hypromellose) Carafate® (methylcellulose , microcrystalline cellulose) Indocin® (tragacanth) Ilevro™ (propylene glycol, carbomer 974P, guar gum, sodium carboxymethylcellulose)
Oral Tablets Opana® ER (original formulation) (TIMERx®-N (xanthan gum and locust bean gum) Aldoril® (cellulose, ethylcellulose, guar gum, hydroxypropyl methylcellulose, magnesium stearate, propylene glycol) Arimidex (hydroxypropylmethylcellulose, polyethylene glycol, povidone, sodium starch glycolate)
Transdermal Patches Lidoderm® (polyacrylic acid, polyvinyl alcohol, sodium carboxymethylcellulose, sodium polyacrylate)
Table 1: Example of hydrophilic rheology modifying polymers used in drug products [10].