Epimastigotes treated for 96h (× 10*6 mL)
Compound Control 0.1mM 1mM 5mM 10mM
1 9.5 ± 0.1 1.4 ± 0.07 1 ± 0.05 0.5 ± 0.07 0
2 17 ± 1 9.8 ± 0.07 8 ± 0.07 2 ± 0.4 0
3 22 ± 2 17 ± 1.4 11 ± 1 0.5 ± 0.1 0
4 28 ± 1 24 ± 1 21 ± 1 19 ± 2 0
5 9 ± 0.4 6 ± 0.1 4 ± 0.1 1.2 ± 0.2 0
6 9 ± 0.6 1.6 ± 0.4 1 ± 0.2 0 0
7 8 ± 0.5 5 ± 0.4 1.6 ± 0.1 0 0
8 8 ± 0.2 3.4 ± 0.07 1.6 ± 0.07 0 0
9 12 ± 0.3 1.4 ± 0.3 1.4 ± 0.1 0 0
10 10 ± 0.3 7.4 ± 0.2 3 ± 0.4 1.2 ± 0.2 0
11 10 ± 0.4 7 ± 0.4 3 ± 0.4 1.8 ± 0.2 0
12 10 ± 0.4 7 ± 0.3 3 ± 0.4 1.9 ± 0.4 0
13 9 ± 0.5 1.4 ± 0.1 1 ± 0.1 0 0
14 11 ± 0.7 5 ± 0.2 4 ± 0.1 1.3 ± 0.2 0
HU 36 ± 2 33 ± 1.8 7 ± 0.5 3.6 ± 0.5 2.4 ± 0.1
BZN 14 ± 1.4 0 0 0 0
Table 1: Epimastigotes of Trypanosomacruzi incubated with compounds (1–14), hydroxyurea (HU) and benznidazole (BZN) (96 h) at 28°C and pH 7.2. Each bar represents the standard deviation. Values are mean ± SD (n=3). The toxic effect of treatment was measured by growing the parasites in LIT for 96 h and quantifying cell live.