| Research Article |
Open Access |
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| Pharmacokinetics of Diminazene Aceturate in Buffalo Calves |
| Hemant Kumar Pandey1, Kaushal Kumar Singh2, Birendra Kumar Roy3* and Suruchi Kumari4 |
| 1Dept. of Pharmacology and Toxicology, Faculty of Veterinary Science & A.H, Birsa Agricultural University, Ranchi - 834006, India |
| 2Dept. of Pathology, Faculty of Veterinary Science & A.H, Birsa Agricultural University, Ranchi - 834006, India |
| 3Dept. of Pharmacology and Toxicology, Faculty of Veterinary Science & A.H, Birsa Agricultural University, Ranchi - 834006, India |
| 4Research Scholor, Dept. of Pharmacology and Toxicology, Faculty of Veterinary Science & A.H, Birsa Agricultural University, Ranchi - 834006, India |
| *Corresponding author: |
Birendra Kumar Roy,
University Professor & Chairman Dept. of Pharmacology and Toxicology,
Faculty of Veterinary Science & A.H,
Birsa Agricultural University, Ranchi - 834006, India,
Tel: 91-651- 2450759,
Fax: 91-651-2450759 |
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| Received February 03, 2010; Accepted March 12, 2010; Published March 12, 2010 |
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| Citation: Pandey HK, Singh KK, Roy BK, Kumari S (2010) Pharmacokinetics of Diminazene Aceturate in Buffalo Calves. J Bioanal Biomed 2: 013- 016. doi:10.4172/1948-593X.1000015 |
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| Copyright: © 2010 Pandey HK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| Abstract |
| The pharmacokinetic study of diminazene aceturate (DMZ) was carried out in two separate groups of 4 each clinically healthy female Murrah buffalo calves after single dose i.v. (8 mg/kg) and i.m. (16 mg/kg) administration. The mean free peak serum concentration of DMZ (CSmax) after i.v. (26.28±0.67μg/ml) and i.m. (8.41±2.43 μg/ml) administrations were obtained at tmax of 5 and 30 min respectively. The DMZ serum concentrations time data were best fitted to the two compartment open model. The calculated serum half life (t½ β) values of DMZ were 15.099±2.504 and 14.225±2.682 h after i.v. and i.m. administration respectively. The mean values of total body clearance rate of DMZ (ClB) after i.m. (3.785±1.119 ml/kg/min) was significantly higher (P<0.05) as compared with the i.v. (0.537±0.063 ml/kg/min). DMZ was highly bound (77.14 to 94.40%) to buffalo calf plasma protein and its penetration into erythrocytes increased with increasing concentrations in blood (7.60 to 33.00μg/ml). Based on pharmacokinetic profiles, the satisfactory dosage regimens of diminazene aceturate in buffalo calves were derived (2 mg/kg, i.v. and 12mg/kg, i.m). In case of emergent disease conditions to ensure high DMZ serum concentrations, i.v. route may be preferred over i.m. route. |
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