| Research Article |
Open Access |
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| Pharmacokinetics of Gentamicin and its Interaction with Paracetamol after i.v. Administration in Buffalo Calves (Bubalus bubalis) |
| Baxla S.L1, Kumar M2, Jayachandran C2, Roy B.K1*and Kumari A2 |
| 1Department of Pharmacology &Toxicology, College of Veterinary Science & A.H, B.A.U., Ranchi-834006, India |
| 2Department of Pharmacology & Toxicology, Bihar Veterinary College, R.A.U., Patna-800014, India |
| *Corresponding author: |
Dr. B.K.Roy, Uni. Prof. & Chairman,
Department of Pharmacology &Toxicology,
College of Veterinary Science & A.H, B.A.U.,
Ranchi-834006, India,
Tel: +91-651-2450759(o),
Fax: +91-651-2450759(o),
E-mail: roybk2001@yahoo.co.in |
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| Received May 20, 2010; Accepted June 28, 2010; Published June 28, 2010 |
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| Citation: Baxla SL, Kumar M, Jayachandran C, Roy BK, Kumari A (2010) Pharmacokinetics of Gentamicin and its Interaction with Paracetamol after i.v. Administration in Buffalo Calves (Bubalus bubalis). J Bioanal Biomed 2: 065-068. doi:10.4172/1948-593X.1000024 |
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| Copyright: © 2010 Baxla SL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| Abstract |
| The disposition kinetics was conducted in five healthy female buffalo calves following single i.v dose (5mg/kg) of gentamicin alone and with paracetamol (40mg/kg,i.v.). The study revealed that the plasma concentrations of gentamicin were significantly higher when it was given with paracetamol as compared to alone between 0.042 to 0.333 hrs and at 24 hrs. Serum concentrations of gentamicin was detected for longer period (48 hrs) in urine in both groups of experimental animals. In case of urine drug attained its peak level at the same time interval (1.5 hrs) in both groups with the concentration of 83.42�3.14 �g/ml after alone and 545.1�25.85 �g/ml with paracetamol administration. The extrapolated zero time plasma concentrations during distribution phase (A) and theoretical zero time plasma concentrations (C�p) were significantly (p< 0.01) higher 34.48�2.35 and 39.03�2.40 �g/ml respectively. Also significantly higher distribution rate constant (a) of 1.935�0.1119 h-1and lower distribution half life (t1/2 a) of 0.36�0.02 hrs were observed, when gentamicin was given with paracetamol. Elimination half life (t1/2�) of 6.67�0.11 hrs was not significantly higher when gentamicin was given with paracetamol. AUC (62.16�2.82 mg/L.hrs) was significantly (p< 0.05) higher while MRT (6.93�0.36hrs) was not significantly higher when gentamicin was given with paracetamol. The values of K12, K21and Kel were calculated to be 1.088�0.111 h-1 , 0.323�0.028 h-1and 0.628�0.024 h-1 respectively when gentamicin was given concurrently with paracetamol. T~P (5.04�0.16) was significantly (p< 0.01) higher, while Vdarea (0.78�0.03L/Kg) and ClB (1.35�0.06 ml/Kg/min) were not significantly higher when gentamicin was given with paracetamol. The present investigation established that both gentamicin and paracetamol interacted with altered their kinetic behaviour. The combination with paracetamol may be benifi cial because paracetamol reduced the maintenance doses of gentamicin which may be much advantageous in the field of veterinary practice in the dose of 5 mg/kg daily by systemic route and 36 hourly when given with paracetamol in urinary tract infection. |
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