Animals treated with Rituximab Immunogenicity results
Binding Antibodies
Week 4 70% (+)
Week 8 70% (+) (same animals as in week 4)
Week 8/10 recovery 50% (+) (one male and one female already positive in weeks 4 and 8)
Neutralizing Antibodies
Week 8 60% (+) (one animal not positive but positive for binding antibodies)
Week 10 recovery 50% (+) (same animals positive for binding antibodies)
Table 2: Determination of binding (ADAs) and neutralizing antibodies in non human primates treated with Rituximab during 8 weeks by the intravenous route.
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