S. No. Property Phytosome Liposome References
1 Bonding It is unit of few molecules bonded together It is an aggregate of many phospholipid molecules that encloses other phytoactive molecules without specifically bonding to them. [11]
2 Bioavailability and Absorption It has much better bioavailability and absorption. Its bioavailability and absorption is lesser than phytosome.  
3 Arrangement of molecules In phytosome, phospholipid (PC) and an individual phytoconstituent are present in 1:1 or 2:1 ratio depending on the substance. In liposomes, hundreds and thousands of phosphatidylcholine molecules surround the water soluble molecule. [12]
Table 1: Difference between phytosome and liposomes.