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Figure 1: Organization of the human Ndufs4 and Ndufa5 locus and its alternative splicing pathways. Bars represent exons and lines introns. The canonical exons are numbered. (Panel A) The Ndufs4 alternative splicing is oform AS#6 and AS#7 (Splice Variants 1 and 2) result from the insertion between exon 2 and exon 3 of a crypto-exon which uses two alternative acceptor sites. The AS#8 (Splice Variant 3) derives from exon 2 skipping [34]. (Panel B) The Ndufa5 alternative splicing isoforms AS#15 and AS#16 result from the insertion between exon 2 and exon 3 and between exon 3 and exon 4 respectively of a non-canonical exon. The AS#17 derives from exon 3 skipping [29].
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