Study group

Cmax

(µg/ml)

AUC0-48

(µg·h/ml)

AUC0-24

(µg·h/ml)

AUC0-∞

(µg·h/ml)

t1/2

(h)

Tmax

(h)

Japanese (N=15)

3.30 ± 1.97 (59.7%)

22.80 ± 9.38 (41.2%)

21.48 ± 9.12 (42.4%)

22.99 ± 9.44 (41.1%)

7.74 ± 1.55 (20.0%)

2.5 (1.5-6.0)

Caucasian (N=15)

3.55 ± 0.84 (23.7%)

23.51 ± 5.65 (24.0%)

22.10 ± 5.01 (22.7%)

23.83 ± 5.63 (23.6%)

9.57 ± 4.79 (50.0%)

4.0 (1.0 -6.0)

 


Cmax: peak plasma concentration, AUC0-48: Area under the plasma concentration versus time curve, Tmax: time at which the Cmax occurs, t1/2: elimination half life For Tmax median and range is reported
Table 2: Summary of pharmacokinetic parameters of valsartan (Arithmetic Mean SD [CV%]).