Formulation / Pharmacokinetic parameter XR-Fed XR-Fasted IR-Fasted P-value     
Auc0→t (ng.mL /hr) 7143
(1671)
5795
(2279)
12459
(3553)
<0.05          
Auc0→∞ (ng.mL /hr) 7448
(1585)
6167
(2236)
12884
(3450)
<0.05          
Cmax (ng/mL) 794
(143)
832
(300)
1956
(476)
<0.05 *
t1/2 (hr) 3.66
(0.8)
3.8
(1.2)
3.39
(0.7)
>0.05          
Kel (hr-1) 0.2
(0.1)
0.19
(0.1)
0.22
(0.1)
>0.05          
Tmax (hr) 6.35
(1.1)
4.3
(1.0)
2.58
(1.0)
< 0.05
> 0.05 for XR-Fed vs XR-Fast Cmax comparison
Table 1: Metformin mean (SD) plasma pharmacokinetic parameters after 1000 mg IR oral dose/ 750 mg XR oral doses to 78 healthy volunteers under different states.
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