Parameter

Test

Vfend™ (reference)

Cmax (ng/mL)

925.73 ± 356.11

1040.25 ± 448.93

Tmax (h)

1.57 ± 0.98

1.38±0.96

AUC0-t (ng/mL*h)

5304.97 ±3072.25

5141.63±2976.92

AUC0-∞ (ng/mL*h)

5783.21 ± 3266.86

5520.69 ± 3148.42

T1/2 (h)

7.80±2.16

6.77±2.05

Cmax, maximum plasma concentration; Tmax, time to peak concentration; AUC0-t, area under plasma concentration-time curve from zero to the last measurable concentration; AUC0-∞, area under plasma concentration time curve from zero to infinity; T1/2, elimination half-life
Table 2: Pharmacokinetic parameters of voriconazole after a single 200-mg oral dose in healthy chinese male volunteers (N = 19).Data are mean ąSD.
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