Fa* Weight (mg)**
(n=20)
Thickness (mm)**
(n=5)
Hardness (kg/cm2)**
(n=6)
Friability (%)**
(n=6)
Drug content (%)**
(n=5)
IR 71.2 ± 1.3 3.23 ± 0.9 4.08 ± 0.5 0.19 ± 0.04 101.05 ± 1.4
F-1 69.71 ± 1.4 3.45 ± 0.05 4.02 ± 0.03 0.17 ± 0.03 98.91 ± 1.2
F-2 69.54 ± 1.56 3.35 ± 0.04 4.04 ± 0.07 0.13 ± 0.02 99.12 ± 1.3
F-3 70.56 ± 1.69 3.65 ± 0.06 4.07 ± 0.06 0.08 ± 0.02 101.1 ± 1.06
F-4 71.67 ± 1.45 3.65 ± 0.08 4.02 ± 0.02 0.07 ± 0.01 99.17 ± 1.4
F-5 68.67 ± 1.56 3.56 ± 0.03 4.03 ± 0.05 0.06 ± 0.03 101.23 ± 1.35
aCode of formulations, bResults represents the mean of replicate determination with the standard deviation given in parenthesis
*Fa – Code of formulations **All values represent mean ±SD (n=3)
Table 2: Comparison of the physical properties of the matrix tablets containing Losartan Potassium.
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