Table 1

	Dopamine receptor		β2-Adrenergic receptor		Histamine H1 Receptor		M3 Muscarinic Acetylcholine Receptor		Mu-Opioid Receptor		a Lipid GPCR		M2 Muscarinic Acetylcholine receptor		Kappa-Opioid receptor		Delta-Opioid receptor		Neurotensin 1 receptor			Chemokine receptor 1			Protease activated receptor 1			5-hydroxy tryptamine receptor 1B			5-hydroxy tryptamine receptor 2B
	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq	TM	Seq		TM	Seq		TM	Seq		TM	Seq		TM
α2a_HUMAN	34%	49%	31%	42%	27%	32%	28%	31%	27%	34%	24%	26%	25%	29%	24%	33%	27%	32%	22%	26%	17%		25%	20%		25%	31%		39%	28%		37%
α2b_HUMAN	32%	49%	28%	41%	26%	33%	26%	29%	26%	34%	24%	28%	24%	27%	24%	35%	27%	32%	19%	26%	16%		30%	18%		28%	28%		37%	29%		41%
α2c_HUMAN	34%	49%	29%	42%	28%	37%	26%	30%	27%	37%	24%	30%	24%	30%	24%	33%	25%	32%	19%	27%	20%		29%	18%		26%	31%		38%	26%		39%

Table 1: Comparison of sequences identities of α-2 ARs with crystal structures of Dopamine Receptor, β2- adrenergic receptor, Histamine H1 receptor, M3 Muscarinic Acetylcholine receptor, Mu-Opioid Receptor, a Lipid GPCR ( Results are based on BLAST and BLAST- 2 Analysis).