Table 3

E×trinsic pathway of apoptosis
Cellular compartment	Reactions	K_m (µM)	V_max (µmol/mg/min)
E×tracellular space and membrane	DL + DR → DR*@Cytosol	1	1×10^-5
E×tracellular space and membrane	DL + DecoryR → DecoryR*@Cytosol	1	1×10^-5
Cytosol	DR* + FADD + Cas8 → Cas8*	4.5	5.8×10^-5
Cytosol	Cas8* + ProCas3 → Cas3*	50	5×10^-5
Intrinsic pathway of apoptosis
Cellular compartment	Reactions	K_m (µM)	V_max (µmol/mg/min)
Mitochondria/ Cytosol	BakR* + Smac → Smac @ cytosol	0.5	5×10^-6
	BidR* + AIF → AIF @ cytosol	0.3	2×10^-5
	Bcl2R* + CytC→ CytC @ cytosol	0.1	8×10^-7
Mitochondrial membrane	Bak + BakR → BakR* @ mitochondria	0.1	5.8×10^-5

Note: The symbol “@” on the right side of an equation indicates the cellular compartment in which the resultant reactant must be registered.

Table 3: Modelling the signal components belonging to pro-apoptosis signalling pathways.