Cellular compartment

Reactions

K_m (µM)

V_max
(µmol/mg/min)

Plasma membrane / Cytosol

OS + PKCδ → PKCδ@Nucleus

1

1×10^-5

Cytosol

PKCδ + DNA damage (Nucleus) → PKCδ@Nucleus

1

1×10^-5

PKCδ + PKCδ (Nucleus) + ProCas3 → Cas3*

10

1×10^-5

Cas3* → Apoptosis

1

0.33

PKCδ + JNK1 → JNK1*

1

1×10^-5

JNK1* + Becli1-Bcl-2 → Beclin1-Bcl-2*

2

4

Beclin1-Bcle-2* → Survival

10

1×10^-8

Nucleus

DNA damage + ATM → ATM*

1

1×10^-5

ATM* + PKCδ → PKCδ*

2

1×10^-3

PKCδ* + p53 → p53*

1

1×10^-3

p53* + DNA damage → Cell cycle arrest

1

1×10^-8

Cell cycle arrest → DNA repair

10

1×10^-8

DNA repair → Cell cycle restart

10

1×10^-8

Cell cycle restart → Survival

10

1×10^-8

p53* +DNA damage → Apoptosis

1000

1×10^-10