Figure 6: Two heat maps of areas under the ROC curve of 276 (= 24 C2 ) conservation score sets using variabilities based upon (A) a substitution matrix and sequence weights and (B) information entropy. The AUC of the conservation score set of 13 different residues between the MpEF-Tu and MgEF-Tu sequences was calculated by using the M193, N194, E204, S343, P345, and T357 residues involving fibronectin binding of the MpEF-Tu molecule [25] as learning data. The positive direction of the learning data defined as ascending order of the 13 conservation scores.