AMD Category                                   First Eye Pigment Abnormalities   Second Eye Drusen Size Drusen Area 1 None or small (<63 μm) <125 μm diameter circle (≈ 5-15 small drusen) none Same as first 2 small (<63 μm) or Intermediate (≥63, <125 μm) None required if pigment abnormalities present ≥125 μm diameter circle At least one druse Absent or present but GA absent Same as first or category 1 3a Intermediate (≥63, <125 μm) Or Large >125 None required if non central GA present ≥360 μm diameter circle if soft indistinct drusen are present (≈20 intermediate drusen) ≥656 μm diameter circle if soft indistinct drusen are absent.  Absent or present but GA absent Same as first or category 1 or 2 3b First eye same category as 3a     Visual Acuity <20.32 due to AMD; or unicolour disqualifying disorder present 4a First eye same category as 1, 2, or 3a     Advanced AMD 4b First eye same category as 1, 2, or 3a     VA<20/32 due to AMD, but advanced AMD not present

Table 1: AREDS AMD categories.