Median age, range

57 yrs., 29-76

% age <65 years vs. ≥65 years

71 vs. 29

Median KPS, range

70, 40-90

% KPS 80-90 vs. 70 vs. <70

40 vs. 29 vs. 31

Median time interval*

35 mo., 5-191

% single brain metastasis

36

Median number of brain metastases

2

% without extracranial metastases

20

% with controlled primary tumour

96

% with grade 1 vs. 2 vs. 3 tumour

4 vs. 47 vs. 49

% with N0 stage vs. 1-3 lymph node metastases vs. more than 3 lymph node metastases

40 vs. 36 vs. 24

Median primary tumour size, range

23 mm, 8-96

% with T1 vs. T2 vs. T3 vs. T4 stage

20 vs. 49 vs. 18 vs. 13

% with Nottingham prognostic index <3.4 vs. 3.4-5.4 vs. >5.4

11 vs. 42 vs. 47

% with triple-negative, HER-2 positive and luminal breast cancer, n=75

20 vs. 44 vs. 36

% in RPA class I vs. II vs. III

4 vs. 64 vs. 31

% with surgical resection of brain metastases before WBRT

9

% with radiosurgery in addition to WBRT

11

KPS: Karnofsky performance status, RPA: recursive partitioning analysis, WBRT: whole brain radiotherapy, * from breast cancer diagnosis to brain metastases
Table 1: Patient characteristics, n=90 (no male patients included).