Parameter |
Univariate (log rank test) |
Multivariate Cox model |
N-stage |
Not significant |
Not included |
Nottingham prognostic index |
Not significant |
Not included |
Hormone receptor status |
Not significant |
Not included |
HER2 status |
Not significant |
Not included |
Extracranial metastases |
Not significant |
Not included |
Number of brain metastases |
Not significant |
Not included |
RPA class II vs. III |
p<0.01 |
Not included* |
Histologic grade 2 vs. 3 |
p=0.03 |
Not significant |
T-size <5 vs. ≥5 cm |
p=0.03 |
Not significant |
KPS |
p<0.01 |
p=0.01**
coefficient -0.28 |
Age |
p=0.02 |
p=0.03**
coefficient 0.04 |
Interval |
p=0.01 |
p=0.04**
coefficient -0.12 |
RPA: recursive partitioning analysis, KPS: Karnofsky performance status,
Interval: primary diagnosis – development of brain metastases
*because age and KPS determine RPA classification (redundancy)
**parameter included as continuous variable |
