n

PI of hormone receptor status

PI of HER-2 status

PI of various factors (multivariate)

Claude et al., 2005

120

none

no data

performance status, lymphopenia

Bartsch et al., 2006

174

none

none

performance status, number of metast. sites

Le Scodan et al., 2007

117

receptor negative sign. worse

none

performance status, lymphopenia, hormone receptor status

Nam et al., 2008

126

receptor negative sign. worse

HER-2 negative sign. worse

number of metast. sites, age, hormone and HER-2 receptor status, leptomeningeal disease

Eichler et al., 2008

83

none

HER-2 negative sign. worse

HER-2 receptor status, number of brain metast., local disease control

Melisko et al., 2008

112

receptor negative sign. worse

none

hormone receptor status, age, performance status, stable or responding systemic disease

Harputluoglu et al., 2008

144

none

none

number of brain metast.

Park et al., 2009

125

none

HER-2 positive sign. worse

HER-2 receptor status, performance status

Altundag et al., 2007

420

receptor negative sign. worse

none

age, hormone receptor status

Niwinska et al., 2009

222

best prognosis in luminal breast cancer

worst prognosis in triple-negative breast cancer

RPA class, biological subtype

Viani et al., 2007

174

no data

no data

extracranial metastases, RPA class

Mahmoud-Ahmed et al., 2002

116

no data

no data

performance status

Present study

90

none

worst prognosis in triple-negative breast cancer

performance status, age, interval

RPA: recursive partitioning analysis
Table 3: Prognostic impact (PI) of different tumour- and patient-related parameters in the literature.