Diagnostic considerations Features not consistent with Cheilitis granulomatosa
Angioedema Swelling resolves in 24-48 hrs and recurs again on antigenic stimulation.
Cheilitis glandularis Inflamed orifices of secretary ducts with red macules on mucosa.
Neurofibroma Slowly progressive enlargement; pathognomonic and histology.
Exfoliative cheilitis It is precipitated by lip biting, trauma, along with the presence of epithelial tags.
Plasma cell cheilitis The classic clinical appearance is a flat-to-slightly raised, eroded plaque or patch, usually on the lower lip of elderly patient.
Sarcoidosis Characteristic skin lesions; mediastinal involvement; lungs and liver involvement.
Crohn's disease Gastrointestinal signs and symptoms; oral ulcerations and fissures.
Tuberculosis Past history of tuberculosis, and other clinical features of TB.
Hemangioma Lesions congenital; vascular proliferation.
Lymphangioma Congenital lesion and characteristic appearance.
Anderson-Fabry disease Characteristic angiokeratomas of skin; history of pain affecting extremities.
Leukemic infiltrate Histologic features of atypical infiltrate; abnormal peripheral WBCs.
Table 1: Differential diagnostic possibility for patients with lip swelling (Sholapurkar et al., 2006; Grave et al., 2009; Rogers and Bekic, 1997).