• Chemokines and chemokine receptors axis can promote oncogenenic and cellular transformation.
  • They act as autocrine growth factors and increase clonal proliferation and tumor angiogenesis mediated by chemokine receptors.
  • They induce production of matrix metalloproteineases in malignant cells, thereby enhancing local invasive potential and metastasis.
  • Targeting chemokines and chemokine receptors in cancer-related inflammation and underlying mechanisms of chemokine action in PC facilitate the development of novel therapies in the future.
  • Table 1: Overview of Chemokines and Chemokine Receptors in Prostate Cancer.