Figure 1: Treatment of T98G xenograft and histopathological evaluation. Combination therapy with ATRA plus IFN-γ caused a significant reduction in tumor volume, compared with control. (A) T98G xenografts following treatment with ATRA, IFN-γ, and ATRA plus IFN-γ. Inset picture shows the tumor in respective group. (B) The bar diagram represents the tumor volume, following treatment. (C) Histopathological features of H&E stained tumor sections showed that control group maintained characteristic growth of glioblastoma, ATRA alone inhibited tumor cell proliferation and caused astrocytic differentiation, IFN-γ alone induced notable amounts of apoptosis, and ATRA plus IFN-γ enhanced amounts of apoptosis.