CENTRAL (MEDULLARY)

a. Conventional high-grade central osteosarcoma b. Telangiectatic osteosarcoma c. Intraosseous well-differentiated (low-grade) osteosarcoma d. Small cell osteosarcoma

SURFACE (PERIPHERAL)

a. Parosteal (juxtacortical) well-differentiated (low-grade) osteosarcoma b. Periosteal osteosarcoma - low- to intermediate-grade osteosarcoma c. High-grade surface osteosarcoma

Table 1: Osteosarcoma subtypes within central and surface tumors (The World Health Organization’s histologic classification of osteosarcoma).