3 or more Performance Status*

Hemoglobin < 8.0 g/dl

White blood count < 3,000/mm3

Platelet count < 100,000/mm3

Total bilirubin > 3 mg/dl

GOT or GPT >150 IU/L

Serums creatinine > 1.5 mg/dl 

Patients with COPD

Patients with coagulopathy

*ECOG score (Oken et al., 1982). GOT, glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; COPD, chronic obstructive pulmonary disease.
Table 1: Exclusion criteria.