Second Primary Tumor Status

Clinical Parameters

None

HNSCC

Lung/ Oesophagus

Remote

p –value*

Age

<65

172 (81%)

18 (8%)

  9 (4%)

14 (7%)

0.230

>65

123 (82%)

10 (7%)

12 (8%)

  5 (3%)

Sex

Male

188 (80%)

22 (9%)

14 (6%)

11 (5%)

0.086

Female

107 (84%)

6 (5%)

  7 (5%)

  8 (6%)

Index Tumour Stage†

1

  87 (85%)

  5 (5%)

6 (6%)

4 (4%)

0.784

2

123 (79%)

16 (10%)

9 (6%)

7 (5%)

3

  62 (82%)

  4 (5%)

4 (5%)

6 (8%)

4

  21 (75%)

  3 (11%)

2 (7%)

2 (7%)

Index Nodal Stage

0

206 (81%)

22 (9%)

14 (5%)

13 (5%)

0.197

1

47 (80%)

  6 (10%)

  1 (2%)

  5 (8%)

2

40 (85%)

  0 (0%)

  6 (13%)

  1 (2%)

3

2 (100%)

  0 (0%)

  0 (0%)

  0 (0%)

Index Clinical Stage†

1

76 (85%)

5 (6%)

4 (4%)

4 (4%)

0.799

2

97 (78%)

14 (11%)

8 (6%)

5 (4%)

3

75 (81%)

6 (6%)

5 (5%)

7 (8%)

4

45 (82%)

3 (5%)

4 (7%)

3 (5%)

Recurrence‡

No Recurrence

147 (74%)

21 (11%)

18 (9%)

14 (7%)

0.001

Local Recurrence Only

  78 (89%)

  7 (8%)

  1 (1%)

  2 (2%)

Nodal Recurrence Only

  39 (98%)

  0 (0%)

  1 (3%)

  0 (0%)

Both Nodal and Local

  31 (91%)

  0 (0%)

  0 (0%)

  3 (9%)

Treatment Modality

Radiotherapy Alone

69 (85%)

3 (4%)

4 (5%)

5 (6%)

0.775

Surgery Alone

119 (81%)

12 (8%)

8 (5%)

8 (5%)

Surgery + Radiotherapy

98 (80%)

12 (10%)

7 (6%)

5 (4%)

Radiotherapy-> Surgery

9 (69%)

1 (8%)

2 (15%)

1 (8%)

Status

Non HNSCC death

100 (66%)

20 (13%)

20 (13%)

11 (7%)

0.000

HNSCC death

123 (98%)

  1 (1%)

  0 (0%)

  2 (2%)

Alive

  72 (84%)

  7 (8%)

  1 (1%)

  6 (7%)

All Cause Death

Yes

223 (81%)

21 (8%)

20 (7%)

13 (5%)

0.177

No

  72 (84%)

  7 (8%)

  1 (1%)

  6 (7%)