Figure 4: Macroscopic effect of treatment on melanoma growth in mice models. Control showed large tumor with areas hemorrhagic (arrows). PHO-S volume reduced of the dorsal tumor and notice that the tumor is surrounded by a fibrillar capsule (arrows). Mice were maintained alive for 180 days and after the last injection on day 50, the control group was sacrificed and the tumor nodules in internal organs were counted. *** P <0.001 are according to One-Way Analysis of Variance ANOVA. (B and C) Control and treatment with Taxol showed a large area vascularized, metastasis in lung parenchyma and lymph nodes. Notice group that received PHO-S no was observed metastasis in lymph nodes (arrows).