Phase II Phase III
Non-small cell lung cancer response rate, progression free survival overall survival, progression free survival
Small-cell lung cancer response rate, progression free survival overall survival, progression free survival
Mesothelioma response rate overall survival
Breast cancer response rate, progression free survival overall survival, progression free survival
Nasopharyngeal carcinoma response rate, time to progression overall survival, progression free survival
Thyroid cancer response rate progression free survival
Esophageal cancer response rate overall survival, progression free survival
Gastric cancer response rate overall survival
Colon rectal cancer response rate, progression free survival overall survival, progression free survival
Pancreatic cancer response rate, progression free survival, overall survival overall survival
Hepatocellular carcinoma response rate, progression free survival overall survival, time to progression
Biliary tract Cancer response rate, progression free survival overall survival
Cervical cancer response rate overall Survival, progression free survival
Endometrial Cancer response rate, progression free survival overall survival, recurrence free survival
Ovarian cancer response rate, progression free survival overall survival, progression free survival
Prostate Cancer time to PSA progression, progression free survival overall survival, progression free survival
Renal cell carcinoma response rate, progression free survival overall survival, progression free survival
Glioblastoma response rate, progression free survival overall survival, progression free survival
Melanoma response rate, Relapse free survival, disease stabilization rate overall survival, progression free survival
Table 1: Main primary endpoints used in advanced or metastatic various types of cancers.