Figure 5: CaneCPI-4 reduces tumor cell development in vivo. Tumor cells (5x104) were injected subcutaneously in C57Bl/6 male (A and B) or female (C and D) mice in the presence of Cane-CPI-4 (open circles), or PBS (control, closed circle). The tumor volume was measured every 2-3 days and the animals were sacrificed at a maximum volume of 3cm3. (A and C) Survival plots. (B and D) Tumor volume of individual animals. Statistical analysis of survivals was performed using Kaplan-Meier test and p value comparing to control is shown in the Figure. Statistical analysis of survivals was performed using Kaplan-Meier test and p value in comparison with the control is shown.