Cell line




Tissue Bone marrow Peripheral blood Peripheral blood
Cell type B lymphocyte IgA kappa B lymphocyte IgA lambda B lymphocyte IgE lambda
Positive for PCA1 Transferrin receptor CD38 PCA1 HLA-DR CD38, CD59; CD52 ILR2  
Unique characteristics NRas active; Amplified c-Myc; Overexpression of t(4;14) and FGFR3 c-Maf over-expression; Sensitive to dexamethasone Produces IL-6; High STAT3 levels; Resistant to Fas
Data are according to ATCC. Ig, immunoglobulin; PCA1, plasma cell-associated antigen; HLA-DR, D-related human leukocyte antigen; FGFR3, fibroblast growth factor receptor 3; IL-6, interleukin 6; STAT3, signal transducers and activators of transcription 3
Table 1: Comparison of the characteristics of three myeloma cell lines.