Number studied Number positive/weak % Immunohistochemistry ALK Cytoplasmic Nuclear Other VS38c/CD138/MUM1 EMA CD45 CD4 CD57 Perforin CD20 CD79a CD30 EBV HHV8 55 44 42 31 45 24 24 49 48 50 17 2 55 48 6 1 44 41 23/2 12/5 3/5 2 4/1 7/2 5 0 0 100 87.3 10.9 1.8 100 97.6 80.6 37.8 33 8 10.2 18.8 10 0 0 ALK – anaplastic lymphoma kinase; EMA – epithelial membrane antigen; EBV – Epstein Barr virus; HHV8 – human herpesvirus 8

Table 3: Immunohistochemical features of 55 cases of ALK-LBCL reported in the literature.