Number studied Number
positive/weak
%
Immunohistochemistry
ALK
Cytoplasmic
Nuclear
Other
VS38c/CD138/MUM1
EMA
CD45
CD4
CD57
Perforin
CD20
CD79a
CD30
EBV
HHV8

55



44
42
31
45
24
24
49
48
50
17
2
55
48
6
1
44
41
23/2
12/5
3/5
2
4/1
7/2
5
0
0
100
87.3
10.9
1.8
100
97.6
80.6
37.8
33
8
10.2
18.8
10
0
0

ALK – anaplastic lymphoma kinase; EMA – epithelial membrane antigen; EBV – Epstein Barr virus; HHV8 – human herpesvirus 8
Table 3: Immunohistochemical features of 55 cases of ALK-LBCL reported in the literature.