| CDDP |
|
5-FU |
|
MTX |
|
CPT |
| Transfected genes |
|
Transfected genes |
|
Transfected genes |
|
Transfected genes |
| Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
| C/EBPa |
N-ras |
|
DAN |
Ha-ras |
|
C/EBPa |
v-Src |
|
DAN |
Ha-ras |
| C/EBPb |
Ha-ras |
|
C/EBPa |
TERT-WT |
|
DAN |
E2F |
|
HSP90 |
N-ras |
| C/EBPb |
PTEN-A3 |
|
Bax* |
v-Src |
|
Caspase-3 |
APP |
|
RhoA-DN |
Akt-DN |
| HSP90 |
HDAC1 |
|
Hsdj |
IkB-TDN |
|
PTEN-G129R |
Akt-DN |
|
C/EBPb |
ErbB2 |
| Hsdj |
DJ1-WT |
|
Cystatin a |
Axin |
|
p53-WT |
Calpain 30K |
|
C/EBPb |
Calpastatin |
| v-Src |
PARK7 |
|
DnaJ |
Rac1 |
|
DnaJ |
cAMP-PK-CS |
|
Caspase-2 |
v-Src |
| COUP |
PTEN-G129R |
|
CyclinD1 |
PKCg-WT |
|
PKCa-KN |
ColXVIII |
|
MKRN1-mut |
Ki-ras |
| p21 |
Caspase-1 |
|
Caspase-3 |
Ki-ras |
|
Ras-N17 |
C/EBPa |
|
CBP |
TERT-WT |
| RhoA-DN |
APC |
|
N-ras |
STAT5A |
|
P/CAF |
WIG1 |
|
PDGF-RD |
HDAC1 |
| FANCC |
CSK |
|
c-Myc |
R-Ras |
|
Decorin |
VDAC1 |
|
p16 |
FilaminA |
|
|
|
|
|
|
|
|
|
|
|
| VP-16 |
|
MIT |
|
MMC |
|
IFM |
| Transfected genes |
|
Transfected genes |
|
Transfected genes |
|
Transfected genes |
| Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
| DAN |
DAP |
|
p53-WT |
MDM2-WT |
|
DAN |
N-ras |
|
C/EBPa |
Ras-N17 |
| C/EBPb |
APC |
|
C/EBPb |
N-ras |
|
MKRN1-mut |
v-Src |
|
TERT-DN |
Akt-DN |
| PTEN-WT |
PARK7 |
|
CAPN10 |
TKT |
|
C/EBPa |
Ha-ras |
|
Hsp70 |
N-ras |
| PKCa-KN |
Ha-ras |
|
Bad |
PARK7 |
|
C/EBPb |
ErbB2 |
|
p53-mut |
Ki-ras |
| AISEC |
HIF1 |
|
PER3 |
HDAC1 |
|
C/EBPb |
Akt-DN |
|
HNF4 |
Ha-ras |
| IkB-TDN |
STAT4 |
|
c-Myc |
Ha-ras |
|
Caspase-2 |
p53 |
|
DnaJ |
Cystatin E |
| Bcl-2 |
STAT6 |
|
TERT-DN |
APC |
|
TERT-DN |
Ki-ras |
|
p16 |
Caspase-1 |
| COUP |
OPRT |
|
Bcl-2 |
Cyclin D1 |
|
Caspase-3 |
TERT-WT |
|
C/EBPb |
v-Src |
| MDM2-mut |
HO |
|
COUP |
MSSP |
|
HSP90 |
Calpastatin |
|
MKRN1-mut |
WIG1 |
| c-Myc |
DJ1-K130R |
|
KRas2-DN |
APC |
|
P/CAF |
Hsp70 |
|
C/EBPb |
p53 |
|
|
|
|
|
|
|
|
|
|
|
| PEP |
|
ACR |
|
VCR |
|
Taxol |
| Transfected genes |
|
Transfected genes |
|
Transfected genes |
|
Transfected genes |
| Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
| MKRN1-mut |
Ki-ras |
|
DAN |
WIG1 |
|
DAN |
OPRT |
|
APC |
Calpain 30K |
| p53-WT |
v-Src |
|
Caspase-2 |
PER2 |
|
p53-WT |
APC |
|
C/EBPb |
Axin |
| ARF1 |
Cystatin a |
|
p16 |
ColXVIII |
|
Decorin |
Rap1A |
|
Caspase-2 |
TSC1 |
| HSP90 |
ErbB2 |
|
Bax |
Caspase-1 |
|
DLG |
FGFR-KR |
|
Decorin |
STAT2 |
| Akt-DN |
N-ras |
|
Caspase-3 |
Ha-ras |
|
p21 |
Rac1 |
|
MDM2-WT |
p53-mut |
| PER3 |
PARK7 |
|
TERT-DN |
TK-1 |
|
C/EBPb |
APC |
|
DLG |
FilaminA |
| DAN |
FGFR-WT |
|
Bax |
RCC1 |
|
p16 |
b-Catenin |
|
Ki-ras |
Akt-DN |
| BH |
HDAC1 |
|
MM1 |
Ki-ras |
|
PER3 |
CRI1 |
|
Max |
STAT3 |
| MDM2-WT |
Calpastatin |
|
TS |
Cystatin a |
|
PER-1 |
RAN |
|
PTEN-WT |
HNF4 |
| Caspase-2 |
PIGPC1 |
|
Max |
ErbB2 |
|
Regucalcin |
c-Myc |
|
RhoA-DN |
Enigma |
|
|
|
|
|
|
|
|
|
|
|
| MCNU |
|
6-TG |
|
AraC |
|
HU |
| Transfected genes |
|
Transfected genes |
|
Transfected genes |
|
Transfected genes |
| Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
|
Resistant |
Sensitive |
| C/EBPb |
Regucalcin |
|
Caspase-3 |
APP |
|
C/EBPb |
AMY1 |
|
DAN |
N-ras |
| Rab1A |
RAN |
|
C/EBPa |
PER2 |
|
MKRN1-mut |
Gluco-R |
|
Bcl-2 |
p21 |
| RhoGDIα |
Akt-DN |
|
DAN |
ColXVIII |
|
OPRT |
Ki-ras |
|
m-Calpain |
ErbB2 |
| ARF1 |
WIG1 |
|
CaMKIIa-CA |
CathL-mut |
|
Bcl-2 |
Ha-ras |
|
Caspase-3 |
HNF4 |
| AISEC |
STMN |
|
Cystatina |
GUK1 |
|
AISEC |
Caspase-3 |
|
TERT-WT |
v-Src |
| MDM2-mut |
STAT6 |
|
HSP90 |
Calpastatin |
|
MDM2-WT |
FGFR-KR |
|
TSC1 |
Ki-ras |
| 14-3-3z |
E2F |
|
C/EBPb |
RPA2 |
|
Decorin |
p53-mut |
|
PTEN-WT |
MDM2-WT |
| IKK-DN |
Caspase-3 |
|
PDGF-RD |
N-ras |
|
Bcl-XL |
RAN |
|
Abl |
STAT4 |
| PKCa-KN |
C/EBPa |
|
HSP40 |
Ha-ras |
|
PKCa-KN |
Bax |
|
HSP90 |
PER-1 |
| cAMP-PK-CS |
HSP40 |
|
HNF1 |
SDC１ |
|
Enigma |
HSP90 |
|
R-Ras |
CaMKIIa |
Listed are top 10 of genes of which the transfection induced drug resistance or sensitization.
The full version of DCI values are shown in Supplementary Table S1.
Abbreviations: WT, wild-type; mut, mutated; DN, dominant negative; KN, kinase negative; TDN, transdominant negative; CA, constitutively active; CS, catalytic subunit. |