Population Diversity dbSNP ID1 Chromosomal Position2 Location (relative to AURKA)3 Alleles1 Amino Acid Change Genotype Frequency in Study Population HapMap-CEU Genotype Frequency1 Patient No.4 Genotypes Genotypes rs1468055 Chr20:54,399,308 Intron C/A N/A 194 C/C 0.585 C/A 0.250 A/A 0.080 C/C 0.567 C/A 0.367 A/A 0.067 rs1468056 Chr20:54,399,395 Intron C/G N/A 156 C/C 0.137 C/G 0.349 G/G 0.349 C/C 0.133 C/G 0.533 G/G 0.333 rs8117896 Chr20:54,389,471 Intron C/T N/A 146 C/C 0.330 C/C 0.198 T/T 0.160 C/C 0.417 C/T 0.433 T/T 0.150 rs2064863 Chr20:54,396,179 Intron A/C N/A 200 A/A 0.202 A/C 0.392 C/C 0.349 A/A 0.150 A/C 0.500 C/C 0.350

Abbreviations: AURKA: Aurora Kinase A; dbSNP: Database Single Nucleotide Polymorphism; chr: Chromosome; HapMap: International HapMap Project; CEU: Population Consisting of Utah Residents with Ancestry from Northern and Western Europe 1Data obtained from NCBI Database of Single Nucleotide Polymorphisms (dbSNP) Build ID: 129, http://www.ncbi.nlm.nih.gov/SNP/, accessed December 2008. Ancestral allele is written first. 2Based on alignment with the NCBI Build 36.1 human reference sequence using the BLAT software, http://genome.ucsc.edu/, accessed December 2008. 3Relative to annotated genomic sequence for human AURKA, chr20: 20q13.2-q13.3. 4Indicates number of patients (n=212) for which the genotyping sequence yielded informative results.

Table 2: AURKA SNP Frequencies among Prostate Cancer Patients.