| Study |
Treatment Period
(year from- to) |
Dose/ delivery of IMRT |
IMRT/ non IMRT: No of Patients |
Primary in oropharnx IMRT/non IMRT |
Type of Study |
Parotid functional Imaging done? |
Salivary output measurements? |
Questionnaire based or rated xerostomia evaluation? |
Salivary function benefit with parotid sparing? |
| Nutting et al. [7] |
2003-2007 |
60-65 Gy in 30 fr, Linac |
47 |
47 |
40 |
40 |
Randomized control trial |
No |
No |
Yes |
Yes |
| van Rij et al. [8] |
1999-2003 |
≥ 60 Gy/ Linear Accelerator (Linac) based |
75 |
87 |
37 |
45 |
Retrospective case-control |
No |
No |
Yes |
Yes |
| Rudat et.al.[9] |
2000-2005 |
≥ 50 Gy/ Linac based |
31 |
69 |
26 |
13 |
Prospective Cohort study |
Yes |
No |
Yes |
Yes |
| Dijkema et al. [10] |
1996-2007 |
≥ 66 Gy Linac based |
64 |
157 |
48 |
28 |
Prospective Cohort study |
No |
Yes (cup) |
No |
No |
| Ortholan et al. [11] |
2001-2004 |
> 50 Gy Linac based |
24 |
20 |
* |
35* |
Prospective Cohort study |
No |
Yes (parafilm chewing) |
No |
Yes |
| Chao et al. [12] |
1970-1999 |
55.1-72 Gy Segmental Tomotherapy |
26 |
404 |
26 |
404 |
Prospective cohort for patients after 1996µ |
No |
No |
Yes |
Yes |
| Daly et al. [13] |
2000-2005 |
60-66 Gy
Linac |
29↑ |
75 |
** |
** |
Retrospective case control |
No |
No |
Yes |
Yes |
| Saarilahti et al. [14] |
2000-2002 |
56-72 Gy Linac |
17 |
0 |
11 |
0 |
Prospective Cohort study |
No |
Yes (paraffin wax chewing) |
Yes |
Yes |
| Parliamen et al. [15] |
2000-2002 |
60-70 Gy Linac |
23 |
0 |
3 |
0 |
Prospective Cohort study |
No |
Yes (spitting ) |
Yes |
Yes |
| Marzi et al. [16] |
2003∞ |
60-70 Gy |
59 |
0 |
9 |
0 |
Prospective Cohort study |
No |
Yes (spitting) |
Yes |
Yes |
| Eisbruch et al. [17] |
1994- 2000 |
56-70 Gy
Linac |
132± |
0 |
56 |
0 |
Prospective Cohort study |
No |
Yes (cup) |
Yes |
Yes |
| Hodge et al. [18] |
1995-2005 |
65.1- 70.4 Gy
Linac |
52 |
143 |
52 |
143 |
Retrospective case control |
No |
No |
Yes |
No |
| Lee et al. [19] |
1998-2004 |
70-72 Gy
Linac |
41 |
71 |
41 |
71 |
Retrospective case control |
No |
No |
Yes |
Yes |
| Rusthoven et al. [20] |
1998-2007 |
66-70 Gy Linac |
32 |
55 |
32 |
55 |
Retrospective case control |
No |
No |
Yes |
Yes |
| Vergeer et al. [21] |
1999- 2004 |
56-70 Gy |
91 |
150 |
34 |
46 |
Prospective Cohort study |
No |
No |
Yes |
Yes |
| Huang et al. [22] |
2000- 2004 |
70 Gy Linac |
71 |
0 |
71 |
0 |
Audit |
No |
No |
Yes |
Yes |
| Anand et al. [23] |
2003-2004 |
66-70 Gy
Linac |
19 |
0 |
7 |
0 |
Prospective Cohort study |
Yes |
No |
Yes |
Yes |
| Lee et al. [24] |
2003- 2004 |
60- 64.8 Gy
Linac |
34 |
0 |
5 |
0 |
Prospective Cohort study |
No |
Yes (spitting) |
Yes |
Yes |
| Pacholke et al. [25] |
1996-2002 |
> 50 Gy
Linac |
27 |
183 |
24 |
78 |
Retrospective case control |
No |
No |
Yes |
Yes |
| Setton et al. [26] |
1998-2009 |
66-70 Gy by conventional fr, linac |
442 |
0 |
442 |
0 |
Prospective Cohort study |
No |
No |
Yes |
Yes |
| Dirix et al. [27] |
2006-2008 |
72 Gy by Linac |
42 |
0 |
12 |
0 |
Prospective Cohort study |
No |
No |
No |
Yes |
| Stock et al. [28] |
2007-2009 |
66-70 Gy by conventional fr, linac |
46 |
0 |
46 |
0 |
Prospective Cohort study |
No |
Yes |
No |
Yes |