| Arruda et al. [3] |
1998- 2004 |
70 Gy |
50 |
50 |
18 |
0 |
0 |
Yes |
3 |
| Huang et al. [22] |
2000-2004 |
70 Gy |
71 |
71 |
33 |
1** |
1.4% |
Yes |
3 |
| Ben-david et al. [38] |
1996-2005 |
56-65 Gy |
176 |
120 |
26 |
0* |
0 |
Yes |
3 |
| Studer et al. [39,40] |
2002- 2007 |
65-72 Gy |
204 |
146 |
20.1 |
1 |
<1% |
Yes |
3 |
| Eisbruch et al. [41] |
2001- 2005 |
66 Gy |
67 |
67 |
32 |
3 |
6% |
Yes |
2 |
| Garden et al. [42] |
2000- 2002 |
63-66 Gy |
51 |
51 |
45 |
1 |
1.96% |
Yes |
3 |
| Gomez et al. [43] |
2000-2007 |
70 Gy |
168 |
41 |
37.4 |
2 |
1.1% |
Yes |
2 |
| Sher et al. [44] |
2004-2009 |
70 Gy |
42 |
42 |
25 |
1 |
2.3% |
Yes |
2 |
| Montejo et al. [45] |
2003-2008 |
67.5 Gy |
43 |
43 |
36.7 |
1 |
2.3% |
Yes |
2 |
|
| *Common Terminolo Gy Criteria for Adverse Events, version 3.0.
**RTOG criteria.
***2.2 Gy per fraction.
¶ 2 of 3 ORN patients had 69 Gy and 70 Gy at the point of ORN, mean mandibular dose was <45 Gy. |
| Table 4: Studies reporting on osteoradionecrosis following IMRT. |