Patient outcome n Relative Risk 95% CI p-value Overall survival 135 1.009 (1.000, 1.017) 0.0386 Local recurrence 135 0.99 (0.974, 1.006) 0.225 Distant metastasis 135 0.999 (0.985, 1.013) 0.8949

Table 4: Impact of treatment delay on overall survival, local and distant metastasis.