Figure 2: Effect of co-administration of mitomycin C and cisplatin with or without the administration of B.aristata on succinate oxidase. The animals were divided into four groups of six animals each. Group-1, received saline, group-2, received a single dose of mitomycin C (2 mg/kg body weight, i.p.) and cisplatin (12 mg/ kg body weight, i.p). Rats were sacrificed 48 h after the administration of drugs. Group-3, received alcoholic extract of B.aristata (10 mg/100 g body weight, oral) for three days. Group-4 recieved alcoholic extract of B.aristata (10 mg/100 g body weight, oral) for three days, followed by single dose of mitomycin C (2 mg/ kg body weight, i.p) and cisplatin (12 mg/kg body weight, i.p). Rats were sacrificed 48 h after the administration of drugs. Rate of respiration was measured using succinate as substrate by the addition of 200 nmols of ADP. It was expressed as n moles of oxygen per minute per milligram protein. RCR is the ratio of ADP stimulated state-3 to ADP exhausted state 4 respiration and P/O=ADP/O ratio. Control values for the rate of respiration, RCR and P/O ratio using succinate as a substrate were 120 11, 4.1 0.31 and 1.85 0.056, respectively. All the values are expressed relative to control, which were taken as 100. *P<0.05, **P <0.01. Values are Mean SD for at least 13 animals.