Figure 7: Putative Pathway involved in Regulation of Apoptosis/Growth check through SMP30. Downregulation of SMP30 leads to high intracellular Ca2+ resulting in p53 induced Bax and downstream PARP mediated apoptosis. Upregulation of SMP30 leads to decrease in intracellular Ca2+ resulting in p53 induced downstream p21 mediated growth check.